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Phospho-PLCγ2 (Tyr759) (G3) rabbit mAb PE conjugate
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|Description||The Phospholipase C (PLC) isozymes hydrolyze phosphatidyl inositolphosphate to inositol triphosphate and diacylglycerol. In response to extracellular stimuli such as hormones, growth factors and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate diacylglycerols (DAGs) and water-soluble phosphorylated derivatives, such as inositol 1,4,5-triphosphate (IP3). Within the PLC family, PLCγ is the only member that contains SH2 and SH3 domains, necessary for phospho PLCγ activation. Phospho PLCγ, upon activation, can interact with receptor tyrosine kinases.|
|Cross Reactivity||Predicted to work with mouse, rat, and other homologues.|
|Formulation||1X PBS, 0.09% NaN3, 0.2% BSA|
|Immunogen||A synthetic phospho-peptide corresponding to residues surrounding Tyr759 of human phospho PLCγ2.|
|Validated Reactivity||Human, Mouse|
|Recommended Usage||For flow cytometric staining, the suggested use of this reagent is 5µL per million cells or 5 µ per 100 µl of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.|
|References||1. Singer, W.D. et al. (1997) Annu. Rev. Biochem. 66, 475–509.
2. Hernandez D, et al. (1994) Genomics 23 (2): 504–507.
3. Smrcka, A.V. et al. (1991) Science 251, 804–807.
4. Taylor, S.J. et al. (1991) Nature 350, 516–518.
Flow cytometric analysis of Ramos cells unstained treated with imatinib (blue) or stained and treated with imatinib (red) or treated with pervanadate (green) using phospho-PLCγ2 (Tyr759) antibody PLCG2Y759-G3 PE conjugate. Cat. #1167.
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