Phospho-PLCγ1 (Tyr783) (C4) rabbit mAb FITC conjugate

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Product Overview
Description The Phospholipase C (PLC) isozymes hydrolyze phosphatidyl inositolphosphate to inositol triphosphate and diacylglycerol. In response to extracellular stimuli such as hormones, growth factors and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate diacylglycerols (DAGs) and water-soluble phosphorylated derivatives, such as inositol 1,4,5-triphosphate (IP3). Within the PLC family, PLCγ is the only member that contains SH2 and SH3 domains, necessary for phospho PLCγ activation. Phospho PLCγ, upon activation, can interact with receptor tyrosine kinases.
Product Details
More Information
Applications Flow Cytometry
Clone PLCG1Y783-C4
Format FITC
Validated Reactivity Human, Mouse
Cross Reactivity Predicted to work with mouse, rat, and other homologues.
Detection Anti-Rabbit IgG
Clonality Monoclonal
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Tyr783 of human phospho PLCγ1.
Formulation 1X PBS, 0.09% NaN3, 0.2% BSA
Isotype Rabbit IgG1k
Preparation Protein A+G
Recommended Usage For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage 2-8ºC
Pseudonyms 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, PLC-148, Phosphoinositide phospholipase C-gamma-1, Phospholipase C-II, Phospholipase C-gamma-1, PLC-gamma-1, PLC1
Uniprot ID P19174
References 1. Singer, W.D. et al. (1997) Annu. Rev. Biochem. 66, 475–509.
2. Hernandez D, et al. (1994) Genomics 23 (2): 504–507.
3. Smrcka, A.V. et al. (1991) Science 251, 804–807.
4. Taylor, S.J. et al. (1991) Nature 350, 516–518.
Cell Culture Products
Flow cytometric analysis of Hela cells unstained imatinib treated cells (blue) or stained treated with imatinib (red) or with pervanadate (green) using phospho-PLCγ1 (Tyr783) antibody PLCg1Y783-C4 FITC conjugate. Cat. #2203.