Cell Surface Antibodies

Plexin domain containing protein 2 (PLXDC2), a cell surface transmembrane protein, is expressed in many tissues including haemotopoeitc stem cells, neural stem cells, pluripotent stem cells, and tumor cells. PLXDC2 may play an important role in neuronal growth, stem cell development, angiogenesis, and cancer cell growth.　Recently PLXDC2 was reported a good cell surface marker as human haemotopoetic stem cells ⁽¹⁾.

PLXDC2 has been reported as a receptor for pigment epithelium derived factor (PEDF) ⁽²⁾ or as an activating ligand for adhesion G-protein coupled receptor D1 (Adgrd1) ⁽³⁾. Also PLXDC2 was thought as a novel interaction partner and an entry receptor for rhesus monkey rhadinovirus (RRV) ⁴⁾. The gene expression level of PLXDC2 was elevated in the peripheral blood of stroke patients ⁽⁵⁾ or in mouse bone marrow-derived macrophages in response to Helicobacter pylori ⁽⁶⁾. The protease BACE1 (β-Site APP Cleaving Enzyme), a major drug target in Alzheimer's disease, cleaves the amyloid precursor protein (APP) as well as PLXDC2 as one of several other substrates ⁽⁷⁾.

Antibody Citation:

1. Sakuma C. et al. Western blotting of native proteins from agarose gels Biotechniques Apr 6 (2022).
2. Akuta T. et al. A new method to characterize conformation-specific antibody by a combination of agarose native gel electrophoresis and contact blotting. Antibodies 11(2), 36. (2022).