PLXDC2 (4G3) rabbit mAb

Catalog
2531
Select Your Size Price
200 uL (0.5 mg/mL)(2531-200 uL (0.5 mg/mL)) $475.00
20 uL (0.5 mg/mL)(2531-20 uL (0.5 mg/mL)) $175.00
$175.00
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Note

20 μL is enough antibody for at least 20 Western blots. 

Product Overview
Description

 

Plexin domain containing protein 2 (PLXDC2), a cell surface transmembrane protein, is expressed in many tissues including haematopoeitc stem cells, neural stem cells, pluripotent stem cells, and tumor cells. PLXDC2 may play an important role in neuronal growth, stem cell development, angiogenesis, and cancer cell growth. PLXDC2 has been reported as a receptor for pigment epithelium derived factor (PEDF) or as an activating ligand for adhesion G-protein coupled receptor D1 (Adgrd1). Also PLXDC2 was thought as a novel interaction partner and an entry receptor for rhesus monkey rhadinovirus (RRV). The gene expression level of PLXDC2 was elevated in the peripheral blood of stroke patients or in mouse bone marrow-derived macrophages in response to Helicobacter pylori. The protease BACE1 (β-Site APP Cleaving Enzyme), a major drug target in Alzheimer’s disease, cleaves the amyloid precursor protein (APP) as well as PLXDC2 as one of several other substrates. 

 

Product Details
More Information
Applications WB, IHC
Clone 4G3
Format Unconjugated
Validated Reactivity Human
Cross Reactivity Predicted to work with mouse.
Detection Anti-Rabbit IgG
Clonality Monoclonal
Immunogen HEK293 cells expression human PLXDC2
Formulation 1 mM HEPES (pH 7.5) , 150 mM NaCl, 50% Glycerol, 0.1% BSA, 0.02% NaN3
Isotype Rabbit IgGk
Preparation Ion Exchange
Recommended Usage WB: 1:1000 - 2000
IHC: 1: 100 4oC overnight
Storage -20ºC
Pseudonyms TEM7R, 1200007L24Rik, 5430431D22Rik
Uniprot ID Q6UX71
References 1. Shimizu H, et al., 2018, Protein Expr Purif, 27-33.
2. Yamamoto N, et al., 2020, Monoclon Antibody Immunodiagn Immunother, 39: 57-60.
Images
Cell Culture Products
Western blot analysis of extracts from HEK293 cells, untransfected or transfected with human PLXDC2 gene using anti-PLXDC2 (4G3) rabbit mAb at 1.0 ug/mL. Cat# 2531
Cell Culture Products
Immunohistochemistry analysis of PLXDC2 using anti-PLXDC2 (4G3) (Cat# 2531) at 8.0 ug/mL staining PLXDC2 in human liver cancer tissue (Human Multi-tissue MicroArray (Cancer), NBP2-30263, Novus Biological).