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Phospho-mTOR (Ser2448) (E11) rabbit mAb PE Conjugate
mTOR, mammalian target of rapamycin, is a Serine/Threonine protein kinase (1-2) that functions as an amino acid and ATP sensor to balance cell growth and nutrient availability (3-4). When sufficient nutrients are available, mTOR transmits a positive signal to p70 S6 kinase and participates in the inactivation of 4E-BP1 (5). mTOR plays a key role in homeostasis and cell growth, and phospho mTOR may be abnormally regulated in tumors. mTOR is a potential target for anti-cancer therapy (6).
|Validated Reactivity||Human, Mouse|
|Cross Reactivity||Predicted to work with mouse, rat and other homologues.|
|Immunogen||A synthetic phospho-peptide corresponding to residues surrounding Ser2448 of human phospho mTOR|
|Formulation||1X PBS, 0.09% NaN3, 0.2% BSA|
|Recommended Usage||For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.|
|Pseudonyms||Serine/threonine-protein kinase mTOR, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, Mammalian target of rapamycin, Mechanistic target of rapamycin, Rapamycin and FKBP12 target 1, Rapamycin target protein 1, FRAP, FRAP1, FRAP2, RAFT1, RAPT1|
|References||1. Sabers, C.J. et al. (1995) J. Biol. Chem. 270: 815-822.
2. Brown, E.J. et al. (1994) Nature. 369: 756-758.
3. Gingras, A.C. et al. (2001) Gene. Dev. 15: 807-826.
4. Dennis, P.B. et al. (2001) Science. 294: 1102-1105.
5. Fang, Y. et al. (2001) Science. 294: 1942-1945.
6. Huang, S. and Houghton, P.J. (2003) Curr. Op. Pharmacol. 3: 371-377.