Phospho-mTOR (Ser2448) (E11) rabbit mAb PE Conjugate

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2377
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100 Tests(2377) $299.00
10 Tests(2377S) $99.00
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Product Overview
Description

mTOR, mammalian target orapamycin, is a Serine/Threonine protein kinase (1-2) that functions as an amino acid and ATP sensor to balance cell growth and nutrient availability (3-4). When sufficient nutrients are available, mTOR transmits a positive signal to p70 S6 kinase and participates in the inactivation of 4E-BP1 (5). mTOR plays a key role in homeostasis and cell growth, and phospho mTOR may be abnormally regulated in tumors. mTOR is a potential target for anti-cancer therapy (6).

Product Details
More Information
Applications Flow Cytometry
Clone mTORS2448-E11
Format PE
Validated Reactivity Human, Mouse
Cross Reactivity Predicted to work with mouse, rat and other homologues.
Detection Anti-Rabbit IgG
Clonality Monoclonal
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Ser2448 of human phospho mTOR
Formulation 1X PBS, 0.09% NaN3, 0.2% BSA
Isotype Rabbit IgGk
Preparation Protein A+G
Recommended Usage For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.
Storage 2-8ºC
Pseudonyms Serine/threonine-protein kinase mTOR, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, Mammalian target of rapamycin, Mechanistic target of rapamycin, Rapamycin and FKBP12 target 1, Rapamycin target protein 1, FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Uniprot ID P42345
References 1. Sabers, C.J. et al. (1995) J. Biol. Chem. 270: 815-822.
2. Brown, E.J. et al. (1994) Nature. 369: 756-758.
3. Gingras, A.C. et al. (2001) Gene. Dev. 15: 807-826.
4. Dennis, P.B. et al. (2001) Science. 294: 1102-1105.
5. Fang, Y. et al. (2001) Science. 294: 1942-1945.
6. Huang, S. and Houghton, P.J. (2003) Curr. Op. Pharmacol. 3: 371-377.
Images
Cell Culture Products
Flow cytometric analysis of A431 cells treated with phosphatase and unstained as negative control (blue) or treated with phosphatase (red) or EGF (green) and stained using Phospho-mTOR (Ser2448) PE conjugated antibody mTORS2448-E11. Cat. #2377.