Phospho-PTEN (Ser380/Thr382/383) (E4) rabbit mAb

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200 uL (0.5 mg/mL)(2131) $475.00
20 uL (0.5 mg/mL)(2131S) $175.00

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20 μL is enough antibody for at least 20 Western blots. 

Product Overview
Description PTEN (phosphatase and tensin homolog, phospho PTEN) was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. Phospho PTEN negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
Product Details
More Information
Applications Flow Cytometry, WB
Clone PTENS380T382383-E4
Format Unconjugated
Cross Reactivity Predicted to work with mouse, rat, and other homologues.
Detection Anti-Rabbit IgG
Formulation 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Ser380 and Thr382/383 of human phospho PTEN
Isotype Rabbit IgG1k
Preparation Protein A+G
Validated Reactivity Human, Mouse
Clonality Monoclonal
Recommended Usage 1.0 - 0.1 µg/ml. Optimum concentration should be determined by the user.
References 1. Cantley, L.C. and Neel, B.G. (1999) Proc Natl Acad Sci USA 96, 4240-5.

2. Myers, M.P. et al. (1997) Proc Natl Acad Sci USA 94, 9052-7.

3. Myers, M.P. et al. (1998) Proc Natl Acad Sci USA 95, 13513-8.

4. Wan X and Helman LJ (2003) Oncogene 22, 8205–11

5. Wu, X. et al. (1998) Proc Natl Acad Sci USA 95, 15587-91.
Storage -20ºC
Cell Culture Products
Flow cytometric analysis of U937 cells secondary antibody only negative control (blue) or untreated (red) or treated with CalA (green) using Phospho-PTEN (Ser380/382/383) antibody PTENS380T382383-E4 at 0.1 µg/mL. Cat. #2131.
Cell Culture Products
Western blot analysis of HEK293 cell extract untreated or treated with lambda phosphatase using Phospho-PTEN (Ser380/Thr382/383) antibody PTENS380T382383-E4. Cat. #2131. Concentration 0.01 µg/mL.
Cell Culture Products
PTENS380T382383-E4 recognizes basal phosphorylation levels in mouse cells. Flow cytometric analysis of L929 cells secondary antibody only (blue) or 0.1 µg/mL of isotype control Cat. #2141 (orange) or of Phospho-PTEN (Ser380/Thr382/383) antibody PTENS380T382383-E4 (green). Cat. #2131.