Phospho-PKCa (Thr497) (F1) rabbit mAb

PKCα is a calcium-dependent isozyme of the PKC family that phosphorylates serine/threonine residues in apoptosis and cellular proliferation and differentiation pathways, including the MAPK cascade. PKCα directly phosphorylated Raf-1, inducing survival genes. An increase in PKCα is associated with multi-drug resistance in cancer cell lines, and increased expression in breast cancers is noted as causing a particularly malignant phenotype. Thus PKCα has been the target of novel cancer therapeutics, with some promising developments in microRNA inhibitors. PKCα is itself phosphorylated by mTOR. PKCα also plays an important role in water regulator and solute absorption in the cell, where it regulates aquaporin 2 by initiating AQP2 ubiquination and lysosomal degradation.