Phospho-p38 MAPK (Thr180/Tyr182) (E3) rabbit mAb PE conjugate

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1157
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100 Tests(1157) $299.00
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Product Overview
Description P38 mitogen-activated protein kinase (MAPK) is a stress-activated serine/threonine protein kinase and belongs to the MAP kinase superfamily. Various stress stimuli such as ultraviolet light, irradiation, heat shock, proinflammatory cytokines, mitogens, and high osmotic stress can activate p38 MAPK through phosphorylation of a TGY motif within the kinase activation loop (1). This event plays an improtant role in cell differentiation, apoptosis and autophagy. MKK3 and SEK activate p38 MAPK by phosphorylation at Thr-180 and Tyr-182. Activated p38 MAPK has been shown to phosphorylate and activate MAPKAP kinase 2 and to phosphorylate the transcription factors ATF2, Mac and MEF2. p38 MAPK also has been shown to phosphorylate post-transcriptional regulating factors like TTP (2).
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Applications Flow Cytometry
Clone P38T180Y182-E3
Format PE
Validated Reactivity Human, Mouse, Rat
Cross Reactivity Predicted to work with mouse, rat and other homologues.
Detection Anti-Rabbit IgG
Clonality Monoclonal
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Thr180/Tyr182 of human phospho p38 MAPK.
Formulation 1X PBS, 0.09% NaN3, 0.2% BSA
Isotype Rabbit IgG1k
Preparation Protein A+G
Recommended Usage For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application.
Storage 2-8ºC
Pseudonyms CSAID-binding protein; CSBP; CSPB1; Cytokine suppressive anti-inflammatory drug-binding protein; EXIP; MAP kinase MXI2; MAPK14; MAX-interacting protein 2; Mitogen-activated protein kinase 14; MK14; MXI2; PRKM14; RK; SAPK2A; stress-activated protein kinase 2A
Uniprot ID Q16539
References (1) Corre I, Paris F, Huot J. (2017) Oncotarget. 8:55684-55714.
(2) Tudor C, Marchese FP, Hitti E, et al. (2009) FEBS Letters. 583: 1933–1938.
Images
Cell Culture Products
Flow cytometric analysis of C6 cells unstained untreated cells (blue) or stained untreated (red) or treated with staurosporine (green) using phospho-p38 MAPK (Thr180/Tyr182) P38MAPKT180Y182-E3 PE conjugate. Cat. #1157.