Legionella pneumophila LPS (serogroup 1) mouse mAb

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Legionella pneumonia, first discovered after an outbreak in Pennsylvania in 1976 at the American Legion convention, is a common cause of community-acquired pneumonia. Legionella are gram-negative bacteria found in natural aquatic environments, where they are intracellular parasites of protozoa. The serogroup 1 strains most commonly cause human infections. Serotyping can be performed by antibody subgrouping, pulsed-field gele electrophoresis, or DNA sequencing. The lipopolysaccharide, LPS or endotoxin, of serogroup 1 is a bacterial virulence factor that contains 10-75 residues of the unique sugar termed legionaminic acid. Lacking free hydroxyl groups renders this LPS hydrophobic, allowing the bacterium to adhere to target cell membranes including macrophages in the lung.
More Information
Applications ELISA
Clone AWB4CE4
Format Unconjugated
Validated Reactivity Other
Cross Reactivity No known reactivity to other Legionella pneumophila serogroups
Detection Anti-Mouse IgG
Clonality Monoclonal
Immunogen LPS conjugated to BSA
Formulation 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Isotype Mouse IgGk
Preparation Protein A+G
Recommended Usage 1µg/mL – 0.001µg/mL. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.
Storage -20ºC
References Ratzow S, Gaia V, Helbig JH, Fry NK, and Luck PC. (2007) Journal of Clinical Microbiology. 45: 1965-1968. Zahringer U, Kinirel YA, Linder B, et al. (1995) Progress in Clinical Biological Research. 392: 113-139.
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