Legionella pneumophila LPS (serogroup 1) mouse mAb
Catalog #: 2026
20 μL is enough antibody for at least 20 Western blots.
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Legionella pneumonia, first discovered after an outbreak in Pennsylvania in 1976 at the American Legion convention, is a common cause of community-acquired pneumonia. Legionella are gram-negative bacteria found in natural aquatic environments, where they are intracellular parasites of protozoa. The serogroup 1 strains most commonly cause human infections. Serotyping can be performed by antibody subgrouping, pulsed-field gele electrophoresis, or DNA sequencing. The lipopolysaccharide, LPS or endotoxin, of serogroup 1 is a bacterial virulence factor that contains 10-75 residues of the unique sugar termed legionaminic acid. Lacking free hydroxyl groups renders this LPS hydrophobic, allowing the bacterium to adhere to target cell membranes including macrophages in the lung.
|Cross Reactivity||No known reactivity to other Legionella pneumophila serogroups|
|Immunogen||LPS conjugated to BSA|
|Formulation||1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA|
|Recommended Usage||1µg/mL – 0.001µg/mL. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.|
|References||Ratzow S, Gaia V, Helbig JH, Fry NK, and Luck PC. (2007) Journal of Clinical Microbiology. 45: 1965-1968.
Zahringer U, Kinirel YA, Linder B, et al. (1995) Progress in Clinical Biological Research. 392: 113-139.
AWB4CE4 antibody shows specific binding to LPS antigen from Legionella pneumophila (serogroup 1).
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