SARS-CoV-2 Epsilon B.1.427 Variant Recombinant Spike Trimer His Tag
Coronaviruses belong to a large family of protein enveloped positive-strand RNA viruses that are known to cause upper respiratory, gastrointestinal, central nervous system diseases in animals and human (1). One of the main proteins on viral envelop is a heavily glycosylated spike (S) protein (2). Trimeric S protein is involved in host receptor angiotensin-converting enzyme 2 (ACE2) recognition and mediates viral entry into cells. It is the principle antigenic determinant of neutralizing antibodies (3). S protein is recognized by humoral immune response during infection leading to inflammatory response. Homotrimeric S protein is a class I fusion protein that forms large protrusions from the virus surface and undergoes a significant structural rearrangement to fuse the viral membrane with the host-cell membrane once it binds to the host receptor (4).
- Cannabinoid Receptor (CB1) (H6) rabbit m...Catalog #: 2521
- Phospho-Histone H3 (Ser10) (4B6) rabbit ...Catalog #: 2061
- Phospho-MKK7 (Ser271/Thr275) (R4F9) rabb...Catalog #: 2159
- Phospho-c-Cbl (Tyr700) (E1) rabbit mAb A...Catalog #: 2324
|Cross Reactivity||Predicted to work with mouse, rat and other homologues.|
|Formulation||1X PBS, 0.025% NaN3|
|Preparation||His tag purification|
|Recommended Usage||Control antigen for SARS-CoV-2 (COVID-19) diagnostic assays. Contains C-terminal His tag used for purification.|
|Pseudonyms||Severe acute respiratory syndrome coronavirus 2 spike protein, 2019-nCoV spike protein|
|References||1.Walls A.C. et al., Cell 2019, 176: 1026-1039.
2.Tang T. et al., 2020, Antiviral Res., 178:10479.
3.Jiang S et al., 2022, Trends Immunol, 41:355-359.
4.Bosch BJ, et al., 2003, J Virol 77:8801-8811.
SARS-CoV-2 XBB Omicron Variant Recombinant Spike Trimer His TagCatalog #: 2700
SARS-CoV-2 BN.1 Omicron Variant Recombinant Spike Trimer His TagCatalog #: 2696