SARS-CoV-2 Epsilon 427 Variant Recombinant Spike Trimer His Tag
Coronaviruses belong to a large family of protein enveloped positive-strand RNA viruses that are known to cause upper respiratory, gastrointestinal, central nervous system diseases in animals and human (1). One of the main proteins on viral envelop is a heavily glycosylated spike (S) protein (2). Trimeric S protein is involved in host receptor angiotensin-converting enzyme 2 (ACE2) recognition and mediates viral entry into cells. It is the principle antigenic determinant of neutralizing antibodies (3). S protein is recognized by humoral immune response during infection leading to inflammatory response. Homotrimeric S protein is a class I fusion protein that forms large protrusions from the virus surface and undergoes a significant structural rearrangement to fuse the viral membrane with the host-cell membrane once it binds to the host receptor (4).
|Cross Reactivity||Predicted to work with mouse, rat and other homologues.|
|Formulation||1X PBS, 0.09% NaN3|
|Preparation||His tag purification|
|Recommended Usage||Control antigen for SARS-CoV-2 (COVID-19) diagnostic assays. Contains C-terminal His tag used for purification.|
|Pseudonyms||Severe acute respiratory syndrome coronavirus 2 spike protein, 2019-nCoV spike protein|
|References||1.Walls A.C. et al., Cell 2019, 176: 1026-1039.
2.Tang T. et al., 2020, Antiviral Res., 178:10479.
3.Jiang S et al., 2022, Trends Immunol, 41:355-359.
4.Bosch BJ, et al., 2003, J Virol 77:8801-8811.
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