SARS-CoV-2 B.1.1.529 Omicron Variant Recombinant Spike Trimer His Tag

Catalog #: 2672
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1mg(2672-1mg) $1440.00
200 uL (0.5 mg/mL)(2672-200) $570.00
20 uL (0.5 mg/mL)(2672-20) $210.00
From $210.00

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Short Description

Coronaviruses belong to a large family of protein enveloped positive-strand RNA viruses that are known to cause upper respiratory, gastrointestinal, central nervous system diseases in animals and human (1). One of the main proteins on viral envelop is a heavily glycosylated spike (S) protein (2). Trimeric S protein is involved in host receptor angiotensin-converting enzyme 2 (ACE2) recognition and mediates viral entry into cells. It is the principle antigenic determinant of neutralizing antibodies (3). S protein is recognized by humoral immune response during infection leading to inflammatory response. Homotrimeric S protein is a class I fusion protein that forms large protrusions from the virus surface and undergoes a significant structural rearrangement to fuse the viral membrane with the host-cell membrane once it binds to the host receptor (4).

Product Details

Product Details
Specification Description
Applications ELISA
Clone COV2-B.1.1.529
Format His tag
Validated Reactivity Human
Cross Reactivity Predicted to work with mouse, rat and other homologues.
Detection Anti-SARS-CoV-2 mAb
Clonality SARS-CoV-2
Formulation 1X PBS, 0.09% NaN3
Isotype SARS-CoV-2
Preparation His tag purification
Recommended Usage Control antigen for SARS-CoV-2 (COVID-19) diagnostic assays. Contains C-terminal His tag used for purification
Storage 2-8ºC
Pseudonyms Severe acute respiratory syndrome coronavirus 2 spike protein, 2019-nCoV spike protein
Uniprot ID XXXXXX
References 1.Walls A.C. et al., Cell 2019, 176: 1026-1039.
2.Tang T. et al., 2020, Antiviral Res., 178:10479.
3.Jiang S et al., 2022, Trends Immunol, 41:355-359.
4.Bosch BJ, et al., 2003, J Virol 77:8801-8811.

Images

Cell Culture Products
SARS-CoV-2 Spike Trimer, His Tag (BA.1.1.529/Omicron) on SDS-PAGE under non-reducing (NR) and reducing (R) conditions. The gel was stained with Coomassie G-250 per manufacturer instructions. The purity of the protein is greater than 95% and it is between 175 and 270 kDa.

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