SARS-CoV-2 Wild Type Wuhan-Hu-1 Strain Recombinant Spike Trimer His Tag

From $210.00
In stock
Only %1 left

Coronaviruses belong to a large family of protein enveloped positive-strand RNA viruses that are known to cause upper respiratory, gastrointestinal, central nervous system diseases in animals and human (1). One of the main proteins on viral envelop is a heavily glycosylated spike (S) protein (2). Trimeric S protein is involved in host receptor angiotensin-converting enzyme 2 (ACE2) recognition and mediates viral entry into cells. It is the principle antigenic determinant of neutralizing antibodies (3). S protein is recognized by humoral immune response during infection leading to inflammatory response. Homotrimeric S protein is a class I fusion protein that forms large protrusions from the virus surface and undergoes a significant structural rearrangement to fuse the viral membrane with the host-cell membrane once it binds to the host receptor (4).

More Information
Applications ELISA
Format Unconjugated
Validated Reactivity Other
Cross Reactivity Predicted to work with mouse, rat and other homologues.
Detection Anti-SARS-CoV-2 mAb
Clonality SARS-CoV-2
Formulation 1X PBS, 0.025% NaN3
Isotype SARS-CoV-2
Preparation His tag purification
Recommended Usage Control antigen for SARS-CoV-2 (COVID-19) diagnostic assays. Contains C-terminal His tag used for purification.
Storage 2-8ºC
Pseudonyms Severe acute respiratory syndrome coronavirus 2 spike protein, 2019-nCoV spike protein
References 1. Walls A.C. et al., 2019 Cell, 176: 1026-1039. 2. Tang T. et al., 2020, Antiviral Res., 178:10479. 3. Jiang S et al., 2022, Trends Immunol, 41:355-359. 4. Bosch BJ, et al., 2003, J Virol 77:8801-8811.
Write Your Own Review
You're reviewing:SARS-CoV-2 Wild Type Wuhan-Hu-1 Strain Recombinant Spike Trimer His Tag
Your Rating