Phospho-Ship2 (Tyr1135) (1D2) rabbit mAb FITC conjugate

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100 Tests(2228) $299.00
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Product Overview

Ship2 (SH2-containing inositol phosphatase 2, phospho Ship2) is a homolog of Ship1. Ship2 is highly expressed in the heart, in skeletal muscle, and in the placenta (1). SHIP2 negatively regulates insulin signaling (2), and Ship2 polymorphisms have been linked to hyperglycemia (3). Phospho Ship2 has been identified as a potential therapeutic target for the treatment of obesity and type 2 diabetes (4,5). The Ship2 residue Tyr1135 is phosphorylated in human cancer cells (6-8).

Product Details
More Information
Applications Flow Cytometry
Clone Ship2Y1135-1D2
Format FITC
Validated Reactivity Human, Mouse
Cross Reactivity Predicted to work with mouse, rat and other homologues.
Detection Anti-Rabbit IgG
Clonality Monoclonal
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Tyr1135 of human phospho Ship2
Formulation 1X PBS, 0.09% NaN3, 0.2% BSA
Isotype Rabbit IgGk
Preparation Protein A+G
Recommended Usage For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.
Storage 2-8ºC
Pseudonyms Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, Inositol polyphosphate phosphatase-like protein 1, INPPL-1, Protein 51C, SH2 domain-containing inositol 5'-phosphatase 2
Uniprot ID O15357
References 1. Goss, V.L. et al. (2006) Blood 107, 4888-97.
2. Rikova, K. et al. (2007) Cell 131, 1190-203.
3. Pesesse, X. et al. (1997) Biochem Biophys Res Commun 239, 697-700.
4. Wada, T. et al. (2001) Mol Cell Biol 21, 1633-46.
5. Ishida, S. et al. (2006) Pancreas 33, 63-7.
6. Dyson, J.M. et al. (2005) Int J Biochem Cell Biol 37, 2260-5.
7. Liang, X. et al. (2006) Proteomics 6, 4554-64.
8. Guo, A. et al. (2008) Proc Natl Acad Sci U S A 105, 692-7.
Cell Culture Products
Flow cytometric analysis of U937 cells untreated (red) or treated with INFa, IL-4 and pervanate (green) using Phospho-Ship2 (Tyr1135) (1D2) Rabbit mAb (FITC Conjugate) Ship2Y1135-1D2 #2228, or concentration-matched Rabbit (G9) mAb IgG Isotype Control (FITC Conjugate) #2143 for cells untreated (black) or treated with IFNa, IL-4 and pervanadate (blue).