Phospho-c-Fos (Ser32) (BA9) rabbit mAb APC Conjugate

Catalog #: 2429
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100 Tests(2429) $299.00
10 Tests(2429S) $99.00
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Product Overview

Description

c-FOS belongs to the Fos family of nuclear oncogenes which include Fos B, Fos-related antigen 1 (FRA1), Fos-related antigen 2 (FRA2) in addition to c-Fos (1). Activator Protein-1 (AP-1) is formed upon dimerization of Fos proteins with Jun protiens (c-Jun, Jun B, and JunD) (2,3). AP-1 is considered a transcription factor that binds to TRE/AP-1 elements and activates transcription. ERK5 is involved with c-Fos phosphorylation at Ser32 and Thr232 which increase c-Fos stability and its nuclear translocation. 

Product Details

Product Details
Specification Description
Applications Flow Cytometry
Clone cFOSS32-BA9
Format APC
Validated Reactivity Human, Mouse, Rat
Cross Reactivity Predicted to work with mouse, rat and other homologues.
Detection Anti-Rabbit IgG
Clonality Monoclonal
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Ser32 of human phospho c-Fos
Formulation 1X PBS, 0.09% NaN3, 0.2% BSA
Isotype Rabbit IgGk
Preparation Protein A+G
Recommended Usage For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.
Storage 2-8ºC
Pseudonyms Proto-oncogene c-Fos, Cellular oncogene fos, G0/G1 switch regulatory protein 7, G0S7
Uniprot ID P01100
References 1. Dobrazanski, P., et al., (1991) Mol Cell Biol, 11:5470-8. 2. Tulchinsky E (2000) Histol Histopathol 15:921-8. 3. Kovary K. and Bravo R. (1992) Mol Cell Biol 12:5015-23.

Images

Cell Culture Products
Flow cytometric analysis of 293-HEK cells untreated (red) or treated with UV+TPA (green) using Phospho-c-FOS (Ser32) (BA9) Rabbit mAb (APC Conjugate), cFosS32-BA9 #2429, or concentration-matched Rabbit (G9) mAb IgG Isotype Control (APC Conjugate) #2144 for cells untreated (black) or treated with UV+TPA (blue).

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