Phospho-Jak1 (Tyr1034/1035) (F11) rabbit mAb FITC Conjugate

From $118.80
In stock
Only %1 left

Jak1 plays an essential role in the IFN-α and IFN-γ response pathways and is tyrosine-phosphorylated upon cellular exposure to these signals. Jak1 oral inhibitors have been used to benefit patients with advanced myelofibrosis, where Jak1 was initially shown to be constitutively active in the peripheral blood cells of these patients. Targeted, small-molecule Jak inhibitors have also been used for treatment of rheumatoid arthritis. In cases of advanced melanoma, acquired resistance to PD-1 blockade drugs is associated with loss-of-functions of mutations in Jak1/2 genes. These mutations block interferon gamma signaling and prevent programmed death ligand 1 (PD-L1) expression in tumor cells.

More Information
Applications Flow Cytometry
Clone Jak1Y10341035-F11
Format FITC
Validated Reactivity Human
Cross Reactivity Predicted to work with mouse, rat and other homologues.
Detection Anti-Rabbit IgG
Clonality Monoclonal
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Tyr1034/1035 of human phospho-Jak1
Formulation 1X PBS, 0.09% NaN3, 0.2% BSA
Isotype Rabbit IgGk
Preparation Protein A+G
Recommended Usage For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.
Storage 2-8ºC
Pseudonyms Tyrosine-protein kinase JAK1, Janus kinase 1
Uniprot ID P23458
References Muller M, et al. (1993) Nature. 366: 129-135. Verstovesk S, et al. (2010) New England Journal of Medicine. 363: 1117-1127. Shin DS, et al. (2017) Cancer Discovery. 7:188-201. Boyle DL, et al. (2014) Annals of the Rheumatic Diseases. 74: 1311-1316.
Write Your Own Review
You're reviewing:Phospho-Jak1 (Tyr1034/1035) (F11) rabbit mAb FITC Conjugate
Your Rating