CTX-M (C11) rabbit mAb

Catalog #: 2626
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200 uL (0.5 mg/mL)(2626-200) $475.00
20 uL (0.5 mg/mL)(2626-20) $175.00
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Short Description

 CTX-M-type enzymes are a group of class A extended-spectrum beta-lactamases (ESBLs) that are rapidly spreading among Entrobacteriaeae worldwide (1). CTX-M-type β-lactamases are plasmid-mediated spread of the gene for β-lactamase with high cefotaxime resolution originally found in Kluyvera spp. Since their discovery in Europe in the early 1980s, they have spread worldwide and are now endemic in Enterobacterales isolated from both hospital-associated and community-acquired infections, including urinary tract infections and bloodstream infections (2). Especially, poor sanitary conditions are more likely to result in the transfer of CTX-M-type enzymes in the Enterobacterales between animals, humans, and living environment. As a result, they are a global public health concern. In the past, TEM- and SHV-type ESBLs were the predominant families of ESBLs. CTX-M-type enzymes have increased since 2000, and today the most commonly found ESBL type with the CTX-M-15 variant dominating worldwide, followed in prevalence CTX-M-14, and CTX-M-27 is emerging in certain parts of the world (3). Presently, more than 50 allelic variants are known, clustered in six sub-lineages or groups.

Note

20 μL is enough antibody for at least 20 Western blots.

More Information

Product Details
Specification Description
Applications ELISA
Clone C11
Format Unconjugated
Validated Reactivity Human
Cross Reactivity Predicted to work with mouse, rat and other homologues.
Detection Anti-Rabbit IgG
Clonality Monoclonal
Immunogen recombinant CTX-M antigen
Formulation 1X PBS, 0.09% NaN3
Isotype Rabbit IgGk
Preparation Ion Exchange
Recommended Usage For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.
Storage -20ºC
Uniprot ID XXXXXX
References 1. Castanheira M et al.,2021, JAC Antimicrob Resis 3(3): diab092.
2. Bonet R, 2004, Antimicrob Agents Chemotherm 48:1-14.
3. Bevan ER., et al., 2017, J Antimicrob Chemother, 72:2145-2155.