Cannabinoid receptor type 2 (CB2) (R4F4) rabbit mAb

Catalog
2561
Select Your Size Price
200 uL (0.5 mg/mL)(2561) $475.00
20 uL (0.5 mg/mL)(2561S) $175.00
$175.00
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Note

20 μL is enough antibody for at least 20 Western blots. 

Product Overview
Description

Cannabinoid receptors (CB) are members of the class A G protein-coupled receptor (GPCR) family. CB1 and CB2 display about 44% amino acid sequence homology (1,2). There are more than 100 different plant-based cannabinoids with different affinities to cannabinoid receptors. The psychoactive drug 9-tetrahydrocannabinol (THC) is the most prominent one. CB1 receptors are mainly expressed in the brain (cerebral cortex, hippocampus, basal ganglia, and cerebellum) as well as peripheral tissues including leukocytes, spleen, tonsils, thymus, heart, and vasculature (3,4). They promote psychotropic and behavioral effects of cannabinoids. Whereas CB2 receptors are expressed in variety of systems including central nervous system (CNSs), cardiovascular system, respiratory system, bone, gastrointestinal system, liver and the reproductive system (5-7). CB2 receptors are attractive target for development for immune-modulating agents, pain management, osteoporosis, and the treatment of liver diseases (8-10).

Product Details
More Information
Applications Flow Cytometry
Clone CB2-R4F4
Format Unconjugated
Validated Reactivity Human
Cross Reactivity Predicted to work with mouse, rat and other homologues.
Detection Anti-Rabbit IgG
Clonality Monoclonal
Immunogen Synthetic peptide
Formulation 1X PBS, 0.09% NaN3, 0.2% BSA
Isotype Rabbit IgGk
Preparation Protein A+G
Recommended Usage For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.
Storage 2-8ºC
Pseudonyms Cannabinoid receptor 2, CB-2, CB2, hCB2, CX5, CNR2
Uniprot ID P34972
References 1. Matsuda LA, et al., (1990) Nature, 346:561-564.
2. Moro O, et al., (1993) J Biol Chem, 268:22273-22276.
3. Howlett AC, et al., (2002) Pharmacol Rev, 54:161-202.
4. Bonz A, et al., (2003) J Cardiovasc Pharmacol, 41:657-664.
5. Onaivi ES, et al., (2006) Ann NY Acad Sci, 1074:514-536.
6. Bab I, and Zimmer A, (2008) Br J Pharmacol, 153:182-188.
7. Maccarrone M, (2008) Br J Pharmacol, 153:189-198.
8. Mbvundula EC, et al., (2004) Inflammopharmacology, 12:99-114.
9. Guindon J, and Hohmann AG, (2008) Br J Pharmacol, 153:319-334.
10. Feng R, et al., (2014) BMC Pharmacol Toxicol, 15:30.
Images
Cell Culture Products
Flow cytometric analysis of HEK293 cells transfected with CB2 (green) or untransfected (red) using CB2-R4F4 antibody at 0.1 ug/mL (Cat. #2521). Secondary only controls with transfected (orange) or untransfected (gray) cells also shown.