||A synthetic phospho-peptide corresponding to residues surrounding Tyr641 of human phospho Stat6
||Predicted to work with mouse, rat and other homologues.
||1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
||WB, Flow Cytometry
||1.0 - 0.1 µg/ml. Optimum concentration should be determined by the user.
Stat6 is a human protein encoded by the STAT6 gene and is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Phospho Stat6 plays a central role in exerting IL-4 and IL-13-mediated biological responses. In addition, Stat6 is activated by IFNα in B cell lines, where phospho Stat6 forms transcriptionally active complexes with Stat2 and p48. Stat6 has been found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL-4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and IgG class switching.
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This product was added to our catalog on Tuesday 25 October, 2016.