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Purified anti-phospho-Stat6 (Tyr641) rabbit mAb

phospho-Stat6 (Tyr641)

Flow cytometric analysis of U937 cells, secondary antibody only negative control (blue) or untreated (red) or treated with IFNa and IL-4 (green) using 0.1 µg/mL Phospho-Stat6 (Tyr641) antibody Stat6Y641-G12. Cat. #1146.

  • phospho-Stat6 (Tyr641)
Catalog Number: 1146
Clonality: Monoclonal
Applications: WB, Flow Cytometry
Reactivity: Mouse, Human
Format: Purified
Conjugate: Unconjugated
Catalog Number: 1146
Clone: Stat6Y641-G12
Isotype: Rabbit IgG1κ
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr641 of human phospho Stat6
Reactivity: Mouse,Human
Cross Reactivity: Predicted to work with mouse, rat and other homologues.
Preparation: Protein A+G
Formulation: 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Storage: -20ºC
Applications: WB, Flow Cytometry
Recommended Usage: 1.0 - 0.1 µg/ml. Optimum concentration should be determined by the user.
Detection: Anti-Rabbit IgG


Stat6 is a human protein encoded by the STAT6 gene and is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Phospho Stat6 plays a central role in exerting IL-4 and IL-13-mediated biological responses. In addition, Stat6 is activated by IFNα in B cell lines, where phospho Stat6 forms transcriptionally active complexes with Stat2 and p48. Stat6 has been found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL-4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and IgG class switching.


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3. Nelms, K. et al., (1999) Ann. Rev. Immunol. 17: 701-738.

4. Malabarba, M.G. et al., (1996) Biochem. J. 319: 865-872.

5. Hou, J. et al., (1994) Science. 265: 1701-1706.

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This product was added to our catalog on Tuesday 25 October, 2016.

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Size(s) Price
20 ul (0.5mg/ml, more than 20 western blots) (1146S) $175.00 
200 ul (0.5mg/ml, more than 200 western blots) (1146) $475.00 

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