||A synthetic phospho-peptide corresponding to residues surrounding Tyr705 of human phospho Stat3
||Predicted to work with mouse, rat and other homologues.
||1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
||1.0 - 0.1 µg/ml. Optimum concentration should be determined by the user.
Stat3 is a key signaling molecule for many cytokines and growth-factor receptors and is required for murine fetal development. Stat3 is constitutively activated in several human tumors and may be involved in oncogenic and anti-apoptotic functions. Phospho Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation and DNA binding. Phospho Stat3 isoform expression appears to reflect biological function: the relative expression levels of Stat3α (86 kDa) and Stat3β (79 kDa) depend on cell type, ligand exposure or maturation stage of the cells. Notably, Stat3β lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain.
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This product was added to our catalog on Sunday 31 July, 2016.