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Purified anti-phospho-SLP-76 (Tyr128) rabbit mAb

phospho-SLP-76 (Tyr128)

Flow cytometric analysis of Ramos cells, secondary antibody only negative control (blue), or untreated (red) or treated with pervanadate (green) using 10 ng/mL Phospho-SLP-76 (Tyr128) antibody SLP76Y128-3F8. Cat. #2136.

  • phospho-SLP-76 (Tyr128)
Catalog Number: 2136
Clonality: Monoclonal
Applications: Flow Cytometry
Reactivity: Mouse, Human
Format: Purified
Conjugate: Unconjugated
Catalog Number: 2136
Clone: SLP76Y128-3F8
Isotype: Rabbit IgG1κ
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr128 of human phospho SLP-76
Reactivity: Mouse,Human
Cross Reactivity: Same target other species with same sequence
Preparation: Protein A+G
Formulation: 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Storage: -20ºC
Applications: Flow Cytometry
Recommended Usage: 1- 0.001 µg/ml. Optimum concentration should be determined by the user.
Detection: anti-rabbit IgG


SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and composed of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues that are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with phospho SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that phospho SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76-deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.



1.  Clements, J.L. (2003) Immunol Rev 191, 211-9.

2.  Bubeck Wardenburg, J. et al. (1998) Immunity 9, 607-16.

3.  Bunnell, S.C. et al. (2000) J Biol Chem 275, 2219-30.

This product was added to our catalog on Friday 30 December, 2016.

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20 ul (0.5mg/ml) (2136S) $175.00 
200 ul (0.5mg/ml) (2136) $475.00 

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