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Purified anti-phospho-S6 Ribosomal Protein (Ser235/236) rabbit mAb

phospho-S6 Ribosomal Protein (Ser235/236)

Flow cytometric analysis of U937 cells, secondary antibody only negative control (blue) or treated with U0126 plus SB20350 (red) or treated with TPA plus calyculin A (green) using Phospho-S6 ribosomal protein (Ser235/Ser236) antibody S6S235S236-R3A2. Cat. #1191.

Catalog Number: 1191
Clonality: Monoclonal
Applications: WB, Flow Cytometry
Reactivity: Mouse, Human
Format: Purified
Conjugate: Unconjugated
Catalog Number: 1191
Clone: S6S235S236-R3A2
Isotype: Rabbit IgG1κ
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Ser235/236 of human phospho S6 Ribosomal Protein
Reactivity: Mouse,Human
Cross Reactivity: Predicted to work with mouse, rat, and other homologues.
Preparation: Protein A+G
Formulation: 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Storage: -20ºC
Applications: WB, Flow Cytometry
Recommended Usage: 1.0 - 0.1 µg/ml. Optimum concentration should be determined by the user.
Detection: Anti-Rabbit IgG


Mammalian ribosomal proteins comprise multigene families that consist predominantly of multiple processed pseudogenes and one functional intron-containing gene within their coding regions. Growth factors and mitogens induce the activation of p70 S6 kinase and the subsequent phosphorylation of the S6 ribosomal protein (40S ribosomal protein phospho S6, Phosphoprotein NP33, RPS6). Phosphorylation of S6 ribosomal protein correlates with an increase in translation of mRNA transcripts that contain an oligopyrimidine tract in their 5' untranslated regions. S6 phosphorylation is stimulated by growth factors, tumor promoting agents and mitogens. It is dephosphorylated at growth arrest. Important S6 ribosomal protein phosphorylation sites include several residues (Ser235, Ser236, Ser240, and Ser244) located within a small, carboxy-terminal region of the phospho S6 protein.



1) Magnuson et al. (2012) Biochemical Journal 441 (1): 1–21.

(2) Ruvinsky et al. (2006) Trends in Biological Sciences 31(6): 342–348.

This product was added to our catalog on Sunday 31 July, 2016.

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Product Price Options

Size(s) Price
20 ul (0.5mg/ml, more than 20 western blots) (1191S) $175.00 
200 ul (0.5mg/ml, more than 200 western blots) (1191) $475.00 

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