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Purified anti-phospho-Rb (Ser807/Ser811) rabbit mAb

phospho-Rb (Ser807/Ser811)

Flow cytometric analysis of Jurkat cells, secondary antibody only negative control (blue) or untreated (red) or treated with calyculin A (green) using Phospho-Rb (Ser807/Ser811) antibody RbS807S811-D9. Cat. #2051.

Catalog Number: 2051
Clonality: Monoclonal
Applications: WB, Flow Cytometry
Reactivity: Mouse, Human
Format: Purified
Conjugate: Unconjugated
Catalog Number: 2051
Clone: RbS807S811-D9
Isotype: Rabbit IgG1κ
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Ser807/Ser811 of human phospho Rb
Reactivity: Mouse,Human
Cross Reactivity: Predicted to work with mouse, rat and other homologues.
Preparation: Protein A+G
Formulation: 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Storage: -20ºC
Applications: WB, Flow Cytometry
Recommended Usage: 1.0 - 0.1 µg/ml. Optimum concentration should be determined by the user.
Detection: Anti-Rabbit IgG


Retinoblastoma protein (Rb, phospho Rb) is a tumor suppressor protein that is inactivated in a numbr of diverse cancers. The antiproliferative activity of Rb is mediated by its ability to inhibit the transcription of genes that are required for cell cycle progression. Rb contains conserved sites that are phosphorylated by cyclin-dependent kinases (CDKs). CDK phosphorylation typically promotes protein-protien interations through creation of a phospho-epitope that becomes structured upon binding its target. However Rb phosphorylation distrupts interactions with its binding partners. When it is phosphorylated, phospho Rb is inactivated and allows execcisve cell growth that is seen in cancer cells. Sixteen potential sites for CDK-mediated phosphorylation exist in Rb and twelve of these sites have been shown to be phosphorylated in vivo


1. Burkhart DL et al., (2008) Nat Rev Cancer. 8:671–682.

2. Knudsen ES (2008) Nat Rev Cancer. 8:714–724.

3. Mittnacht S. (1998) Curr Opin Genet Dev. 8:21–27. 

4. Weinberg RA. (1995) 81:323–330.

5. Henley SA et al., (2012) Cell Div., 7:10. 

This product was added to our catalog on Friday 30 September, 2016.

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Product Price Options

Size(s) Price
20 ul (0.5mg/ml, more than 20 western blots) (2051S) $175.00 
200 ul (0.5mg/ml, more than 200 western blots) (2051) $475.00 

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