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Purified anti-phospho-PTEN (Ser380/Thr382/383) rabbit mAb

phospho-PTEN (Ser380/Thr382/383)

Flow cytometric analysis of U937 cells, secondary antibody only negative control (blue) or untreated (red) or treated with CalA (green) using Phospho-PTEN (Ser380/382/383) antibody PTENS380T382383-E4 at 0.1 µg/mL. Cat. #2131.

  • phospho-PTEN (Ser380/Thr382/383)
Catalog Number: 2131
Clonality: Monoclonal
Applications: WB, Flow Cytometry
Reactivity: Mouse, Human
Format: Purified
Conjugate: Unconjugated
Catalog Number: 2131
Clone: PTENS380T382383-E4
Isotype: Rabbit IgG1κ
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Ser380 and Thr382/383 of human phospho PTEN
Reactivity: Mouse,Human
Cross Reactivity: Predicted to work with mouse, rat, and other homologues.
Preparation: Protein A+G
Formulation: 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Storage: -20ºC
Applications: WB, Flow Cytometry
Recommended Usage: 1.0 - 0.1 µg/ml. Optimum concentration should be determined by the user.
Detection: Anti-Rabbit IgG


PTEN (phosphatase and tensin homolog, phospho PTEN) was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. Phospho PTEN negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. 


1.  Cantley, L.C. and Neel, B.G. (1999) Proc Natl Acad Sci USA 96, 4240-5.

2.  Myers, M.P. et al. (1997) Proc Natl Acad Sci USA 94, 9052-7.

3.  Myers, M.P. et al. (1998) Proc Natl Acad Sci USA 95, 13513-8.

4.  Wan X and Helman LJ (2003) Oncogene 22, 8205–11

5.  Wu, X. et al. (1998) Proc Natl Acad Sci USA 95, 15587-91.


This product was added to our catalog on Friday 30 December, 2016.

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Size(s) Price
20 ul (0.5mg/ml, more than 20 western blots) (2131S) $175.00 
200 ul (0.5mg/ml, more than 200 western blots) (2131) $475.00 

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