||A synthetic phospho-peptide corresponding to residues surrounding Ser380 and Thr382/383 of human phospho PTEN
||Predicted to work with mouse, rat, and other homologues.
||1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
||WB, Flow Cytometry
||1.0 - 0.1 µg/ml. Optimum concentration should be determined by the user.
PTEN (phosphatase and tensin homolog, phospho PTEN) was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. Phospho PTEN negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
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This product was added to our catalog on Friday 30 December, 2016.