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Conjugated anti-phospho-PLCγ2 (Tyr759) PE rabbit mAb

phospho-PLCγ2 (Tyr759) PE

Flow cytometric analysis of Ramos cells, unstained cells negative control (blue), or stained and untreated (red) or treated with pervanadate (green) using Phospho-PLCγ2 (Tyr759) PE conjugate antibody PLCG2Y759-G3. Cat. #1167.

Catalog Number: 1167
Clonality: Monoclonal
Applications: Flow Cytometry
Reactivity: Mouse, Human
Format: Conjugated
Conjugate: PE
 
Catalog Number: 1167
Clone: PLCG2Y759-G3
Isotype: Rabbit IgG1κ
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr759 of human phospho PLCγ2.
Reactivity: Mouse,Human
Cross Reactivity: Predicted to work with mouse, rat, and other homologues.
Preparation: Protein A+G
Formulation: 1X PBS, 0.09% NaN3, 0.2% BSA
Storage: 2-8ºC
Applications: Flow Cytometry
Recommended Usage: For flow cytometric staining, the suggested use of this reagent is 5 μl per million cells or 5 μl per 100 μl of staining vlolume. It is recommended that the reagent be titrated for optimal performance for each application
Detection: Anti-Rabbit IgG

Description:

The Phospholipase C (PLC) isozymes hydrolyze phosphatidyl inositolphosphate to inositol triphosphate and diacylglycerol. In response to extracellular stimuli such as hormones, growth factors and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate diacylglycerols (DAGs) and water-soluble phosphorylated derivatives, such as inositol 1,4,5-triphosphate (IP3). Within the PLC family, PLCγ is the only member that contains SH2 and SH3 domains, necessary for phospho PLCγ activation. Phospho PLCγ, upon activation, can interact with receptor tyrosine kinases.

 

References:

1. Singer, W.D. et al. (1997) Annu. Rev. Biochem. 66, 475–509.

2.  Hernandez D, et al. (1994) Genomics 23 (2): 504–7.

3. Smrcka, A.V. et al. (1991) Science 251, 804–807.

4. Taylor, S.J. et al. (1991) Nature 350, 516–518.

This product was added to our catalog on Wednesday 28 September, 2016.

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10 tests (1167S) $99.00 
100 tests (1167) $299.00 
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