||A synthetic phospho-peptide corresponding to residues surrounding Tyr759 of human phospho PLCγ2.
||Predicted to work with mouse, rat, and other homologues.
||1X PBS, 0.09% NaN3, 0.2% BSA
||For flow cytometric staining, the suggested use of this reagent is 5 μl per million cells or 5 μl per 100 μl of staining vlolume. It is recommended that the reagent be titrated for optimal performance for each application
The Phospholipase C (PLC) isozymes hydrolyze phosphatidyl inositolphosphate to inositol triphosphate and diacylglycerol. In response to extracellular stimuli such as hormones, growth factors and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate diacylglycerols (DAGs) and water-soluble phosphorylated derivatives, such as inositol 1,4,5-triphosphate (IP3). Within the PLC family, PLCγ is the only member that contains SH2 and SH3 domains, necessary for phospho PLCγ activation. Phospho PLCγ, upon activation, can interact with receptor tyrosine kinases.
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This product was added to our catalog on Wednesday 28 September, 2016.