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Purified anti-phospho-ATF2 (Thr71) rabbit mAb

phospho-ATF2 (Thr71)

Flow cytometric analysis of Jurkat cells, secondary antibody only negative control (blue) or untreated (red) or treated with anisomycin (green) using Phospho-ATF-2 (Thr71) antibody ATF2T71-G3 at 0.1 µg/mL. Cat #2056.

  • phospho-ATF2 (Thr71)
  • phospho-ATF2 (Thr71)
Catalog Number: 2056
Clonality: Monoclonal
Applications: WB, Flow Cytometry
Reactivity: Mouse, Human
Format: Purified
Conjugate: Unconjugated
 
Catalog Number: 2056
Clone: ATF2T71-G3
Isotype: Rabbit IgG1κ
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Thr71 of human phospho ATF2
Reactivity: Mouse,Human
Cross Reactivity: Predicted to work with mouse, rat and other homologues.
Preparation: Protein A+G
Formulation: 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Storage: -20ºC
Applications: WB, Flow Cytometry
Recommended Usage: 1.0 - 0.1 µg/ml. Optimum concentration should be determined by the user.
Detection: Anti-Rabbit IgG

Description:

Activating transcription factor 2,  also known as phospho ATF2, is a protein that, in humans, is encoded by the ATF2 gene.Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex. Cellular stress phosphorylates Thr69 and Thr71 and activates phospho ATF-2.

 

 

References:

1. Kawasaki H, et al. (2000) Nature 405:195-200.

2. Bhoumik A, Tet al. Ronai Z. (2005) Mol. Cell 18:577-87.

3. Bhoumik A, et al. (2008) J. Biol. Chem. 283:17605-14. 

4. Lau E, et al., (2012) Cell 148: 543-55.

 

 

 

This product was added to our catalog on Monday 26 September, 2016.

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Size(s) Price
20 ul (0.5mg/ml, more than 20 western blots) (2056S) $175.00 
200 ul (0.5mg/ml, more than 200 western blots) (2056) $475.00 
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