||A synthetic phospho-peptide corresponding to residues surrounding Thr71 of human phospho ATF2
||Predicted to work with mouse, rat and other homologues.
||1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
||WB, Flow Cytometry
||1.0 - 0.1 µg/ml. Optimum concentration should be determined by the user.
Activating transcription factor 2, also known as phospho ATF2, is a protein that, in humans, is encoded by the ATF2 gene.Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex. Cellular stress phosphorylates Thr69 and Thr71 and activates phospho ATF-2.
1. Kawasaki H, et al. (2000) Nature 405:195-200.
2. Bhoumik A, Tet al. Ronai Z. (2005) Mol. Cell 18:577-87.
3. Bhoumik A, et al. (2008) J. Biol. Chem. 283:17605-14.
4. Lau E, et al., (2012) Cell 148: 543-55.
This product was added to our catalog on Monday 26 September, 2016.