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Purified anti-Human/Mouse Myl9/12 rabbit mAb

Human/Mouse Myl9/12

Catalog Number: 1151
Clonality: Monoclonal
Applications: Functional Assay, ELISA, IHC
Reactivity: Mouse, Human
Format: Purified
Conjugate: Unconjugated
Catalog Number: 1151
Clone: AWBMyl9F6 (F-6)
Isotype: Rabbit IgG1κ
Immunogen: N-terminal peptide of Myl9
Reactivity: Mouse,Human
Cross Reactivity: Antibody may react with the same target protein from other species sharing the same sequence.
Preparation: Protein A+G
Formulation: PBS, 0.09% Azide
Storage: 2-8ºC
Applications: Functional Assay, ELISA, IHC
Recommended Usage: Optimum concentration should be determined by the user.
Detection: Anti-Rabbit IgG

Description:

Myosin regulatory light polypeptide 9 is a highly conserved, ubiquitously expressed protein that in humans is encoded by the MYL9 gene.  Myosin, a structural component of muscle, are hexameric proteins consisting of two heavy chains and four light chains, including a single pair of nonphosphorylatable light chain subunits and another pair of phosphorylatable light chain subunits.The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads.

Myosin light chain (Myl) 9 and Myl12 are new functional ligands for CD69. Blockade of CD69-Myl9/12 interactio ameliorates allergic airway inflammation in ovalbumin-induced and house dust mite-induced mouse models of asthma.(1) This rabbit monoclonal antibodies against Myl9/12 (clone F-6) is made by immunization with N-terminal peptide of Myl9.

References:

1.     K. Hayashizaki, M. Kimura, K. Tokoyoda, et al. (2016) Science Immunology, 1:eaaf9154.

2.     "Entrez Gene: myosin".

 

This product was added to our catalog on Wednesday 07 September, 2016.

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Size: 100 µg (1151)
Price: $349.00 
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