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Antibody Affinity Maturation

Antibody Affinity Maturation

Abwiz Bio offers antibody affinity maturation services for your antibody lead candidate. Our antibody affinity maturation team has extensive experience creating synthetic libraries and performing selection to engineer antibodies with picomolar (KD) affinity.

Abwiz Bio’s proprietary phage selection platform has unique advantages that make it ideal for antibody affinity maturation applications:

  • Selection on recombinant protein or cell-surface based antigens

    • With the proper screening protocols, library selection can even be performed using crude antigen preparations or poorly-characterized cell-surface receptor targets. In vitro selection provides careful control over the binding conditions – optimal for specialized applications.

  • Accurate and precise control over library diversity

    • Our unique library construction methods allow for accurate targeting of single or multiple sites of mutagenesis as well as precise control over the exact amino acid composition at each targeted residue.

  • Maximal diversity

    • Phage libraries are typically 109-1011 in size - orders of magnitude higher than cell-based selection methods. By maximal sampling of the mutational space, you can help ensure that the antibody-antigen interaction is fully optimized.

We will work with your team to design the best approach unique to your intended application. We are confident that our antibody affinity maturation technology can help you make a more robust, effective antibody.